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KMID : 0385019990150010053
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Korean Journal of Laboratory Animal Science
1999 Volume.15 No. 1 p.53 ~ p.59
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Pathology of Disseminated Intravascular Coagulation in Rabbit Viral Hemorrhagic Disease
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박남용/Park, Nam Yong
한동운/장희성/강문일/박영석/Han, Dong Un/Chang, Hee Sung/Kang, Mun II/Park, Young Seok
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Abstract
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In order to elucidate the role of disseminated intravascular coagulation (DIC) in pathogenesis of rabbit viral hemorrhagic disease (RVHD), ten rabbits were inoculated with rabbit viral hemorrhagic disease virus (RVHD), and then examined clinical sings, and gross and histopathological findings, and performed hematological and biochemical analysis. Three healthy rabbits were also used as the control.
The main clinical signs were characterized by depression, anorexia, anuria, and recumbency with limb rowing, and the histopathological findings included marked congestion, hemorrhage, and focal necrosis and numerous marked microthombi formation in liver, lungs, kidneys, adrenals and heart or spleen. With time after inoculation, platelets were reduced in number of rabbits, and also prothrombin time and activated partial thromboplastin time were considerably prolonged, and fibrinogen level was decreased. Both alanine aminotransferase and aspartate aminotransferase values were markedly increased after inoculation of RVHD virus.
These results suggested that DIC might be one of the major causes for sudden death in rabbits infected with RVHD virus.
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